SKEMPI v2.0
Structural database of Kinetics and Energetics of Mutant Protein Interactions
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Records per page:
5
10
20
50
PDB Database to use:
PDBe
RCSB
PDBj
Mutations
PDB Code
Mutation Pdb
Mutation Cleaned
Location
Hold Out Type
Hold Out Proteins
Affinity Mut
Affinity Wt
Ref.
Protein 1
Protein 2
T (ºK)
Kon Mut
Kon Wt
Koff Mut
Koff Wt
Dh Mut
Dh Wt
Ds Mut
Ds Wt
Method
=
!=
<
>
<=
>=
starts with
contains
in
not in
=
!=
<
>
<=
>=
starts with
contains
in
not in
=
!=
<
>
<=
>=
starts with
contains
in
not in
=
!=
<
>
<=
>=
starts with
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in
not in
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!=
<
>
<=
>=
starts with
contains
in
not in
=
!=
<
>
<=
>=
starts with
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in
not in
=
!=
<
>
<=
>=
starts with
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in
not in
=
!=
<
>
<=
>=
starts with
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in
not in
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!=
<
>
<=
>=
starts with
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in
not in
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!=
<
>
<=
>=
starts with
contains
in
not in
=
!=
<
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<=
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starts with
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not in
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<
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<=
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starts with
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in
not in
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!=
<
>
<=
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starts with
contains
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not in
=
!=
<
>
<=
>=
starts with
contains
in
not in
=
!=
<
>
<=
>=
starts with
contains
in
not in
=
!=
<
>
<=
>=
starts with
contains
in
not in
=
!=
<
>
<=
>=
=
!=
<
>
<=
>=
=
!=
<
>
<=
>=
=
!=
<
>
<=
>=
=
!=
<
>
<=
>=
starts with
contains
in
not in
7085 records found
PDB Code
Mutation Pdb▲
Mutation Cleaned
Location
Hold Out Type
Hold Out Proteins
Affinity Mut
Affinity Wt
Ref.
Protein 1
Protein 2
T (ºK)
Kon Mut
Kon Wt
Koff Mut
Koff Wt
Dh Mut
Dh Wt
Ds Mut
Ds Wt
Method
1R0R_E_I
YI20H
YI15H
COR
Pr/PI
Pr/PI
5E-09
2.94E-11
Subtilisin Carlsberg
Turkey ovomucoid third domain
294
None
None
None
None
FL
3SGB_E_I
YI20H
YI14H
COR
Pr/PI
Pr/PI
1.92E-10
1.79E-11
Streptomyces griseus proteinase B
Turkey ovomucoid third domain
294
None
None
None
None
FL
1PPF_E_I
YI20H
YI20H
COR
Pr/PI
Pr/PI
1.03E-08
1.64E-10
Human leukocyte elastase
Turkey ovomucoid third domain
294
None
None
None
None
FL
1CHO_EFG_I
YI20I
YI17I
COR
Pr/PI
Pr/PI
1.85E-10
5.26E-12
Bovine alpha-chymotrypsin
Turkey ovomucoid third domain
294
None
None
None
None
FL
1PPF_E_I
YI20I
YI20I
COR
Pr/PI
Pr/PI
1.25E-07
1.64E-10
Human leukocyte elastase
Turkey ovomucoid third domain
294
None
None
None
None
FL
1R0R_E_I
YI20I
YI15I
COR
Pr/PI
Pr/PI
3.7E-09
2.94E-11
Subtilisin Carlsberg
Turkey ovomucoid third domain
294
None
None
None
None
FL
3SGB_E_I
YI20I
YI14I
COR
Pr/PI
Pr/PI
7.69E-09
1.79E-11
Streptomyces griseus proteinase B
Turkey ovomucoid third domain
294
None
None
None
None
FL
1CHO_EFG_I
YI20K
YI17K
COR
Pr/PI
Pr/PI
1.1E-09
5.26E-12
Bovine alpha-chymotrypsin
Turkey ovomucoid third domain
294
None
None
None
None
FL
1PPF_E_I
YI20K
YI20K
COR
Pr/PI
Pr/PI
3.23E-07
1.64E-10
Human leukocyte elastase
Turkey ovomucoid third domain
294
None
None
None
None
FL
1R0R_E_I
YI20K
YI15K
COR
Pr/PI
Pr/PI
3.23E-07
2.94E-11
Subtilisin Carlsberg
Turkey ovomucoid third domain
294
None
None
None
None
FL
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