SKEMPI v2.0
Structural database of Kinetics and Energetics of Mutant Protein Interactions
1A22_A_B
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- Mutation(s) in PDB:
FA25A,
YA42A,
QA46A
- Mutation(s) cleaned: FA25A,YA42A,QA46A
- Location: COR,COR,RIM
- Hold out type:
- Hold out protein(s): 1A22_A_B,1BP3_A_B
- Affinity mutant: 3.68E-09
- Affinity wild-typen: 2.6E-09
- Reference: 8756685
- Protein 1: Human growth hormone
- Protein 2: hGH binding protein
- Method: ITC
- Temperaute: 298(assumed) K
- Kon mutatant (M-1s-1): -
- Kon wild-type (M-1s-1): -
- Koff mutatant (M-1s-1): -
- Koff wild-type (M-1s-1): -
- ΔH mutant (kcal mol-1)): -12.2
- ΔH wild-type (kcal mol-1)): -9.4
- ΔS mutant (cal mol-1 K-1): -2.3
- ΔS wild-type (cal mol-1 K-1): 7.7