2VLR_ABC_DE

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  • Mutation(s) in PDB: AE99S
  • Mutation(s) cleaned: AE95S
  • Location: SUP
  • Hold out type: TCR/pMHC
  • Hold out protein(s): TCR/pMHC,1JCK_A_B
  • Affinity mutant: 5.24E-06
  • Affinity wild-typen: 5.24E-06
  • Reference: 18275829
  • Protein 1: HLA-A2 plus flu peptide
  • Protein 2: JM22 TCR
  • Method: ITC
  • Temperaute: 298 K
  • Kon mutatant (M-1s-1): -
  • Kon wild-type (M-1s-1): -
  • Koff mutatant (M-1s-1): -
  • Koff wild-type (M-1s-1): -
  • ΔH mutant (kcal mol-1)): -23.0
  • ΔH wild-type (kcal mol-1)): -18.0
  • ΔS mutant (cal mol-1 K-1): -50.3
  • ΔS wild-type (cal mol-1 K-1): -33.5