SKEMPI v2.0
Structural database of Kinetics and Energetics of Mutant Protein Interactions
2P5E_ABC_DE
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- Mutation(s) in PDB:
TD51P,
PD52F,
AE49S,
IE50V,
QE51G,
TE52M,
LD95T,
LD96S,
DD97G,
TD99S,
LE94V
- Mutation(s) cleaned: TD52P,PD53F,AE49S,IE50V,QE51G,TE52M,LD96T,LD97S,DD98G,TD100S,LE94V
- Location: SUP,INT,COR,COR,RIM,COR,COR,RIM,RIM,COR,COR
- Hold out type: TCR/pMHC
- Hold out protein(s): TCR/pMHC,1JCK_A_B,4N8V_G_ABC
- Affinity mutant: 1.31E-09
- Affinity wild-typen: 4.77E-11
- Reference: 17644531
- Protein 1: HLA-A2 plus NY-ESO peptide
- Protein 2: 1G4 TCR
- Method: SPR
- Temperaute: 298(assumed) K
- Kon mutatant (M-1s-1): 1.81E+05
- Kon wild-type (M-1s-1): 5.7E+05
- Koff mutatant (M-1s-1): 2.37E-04
- Koff wild-type (M-1s-1): 2.72E-05
- ΔH mutant (kcal mol-1)): None
- ΔH wild-type (kcal mol-1)): None
- ΔS mutant (cal mol-1 K-1): None
- ΔS wild-type (cal mol-1 K-1): None