2P5E_ABC_DE

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  • Mutation(s) in PDB: TD51Q, PD52S, WD53S, AE49G, IE50A, QE51G
  • Mutation(s) cleaned: TD52Q,PD53S,WD54S,AE49G,IE50A,QE51G
  • Location: SUP,INT,COR,COR,COR,RIM
  • Hold out type: TCR/pMHC
  • Hold out protein(s): TCR/pMHC,1JCK_A_B,4N8V_G_ABC
  • Affinity mutant: 8.15E-08
  • Affinity wild-typen: 4.77E-11
  • Reference: 17644531
  • Protein 1: HLA-A2 plus NY-ESO peptide
  • Protein 2: 1G4 TCR
  • Method: SPR
  • Temperaute: 298(assumed) K
  • Kon mutatant (M-1s-1): 1.78E+04
  • Kon wild-type (M-1s-1): 5.7E+05
  • Koff mutatant (M-1s-1): 1.45E-03
  • Koff wild-type (M-1s-1): 2.72E-05
  • ΔH mutant (kcal mol-1)): None
  • ΔH wild-type (kcal mol-1)): None
  • ΔS mutant (cal mol-1 K-1): None
  • ΔS wild-type (cal mol-1 K-1): None