SKEMPI v2.0
Structural database of Kinetics and Energetics of Mutant Protein Interactions
2P5E_ABC_DE
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- Mutation(s) in PDB:
TD51Q,
PD52S,
WD53S,
AE49G,
IE50A,
QE51G
- Mutation(s) cleaned: TD52Q,PD53S,WD54S,AE49G,IE50A,QE51G
- Location: SUP,INT,COR,COR,COR,RIM
- Hold out type: TCR/pMHC
- Hold out protein(s): TCR/pMHC,1JCK_A_B,4N8V_G_ABC
- Affinity mutant: 8.15E-08
- Affinity wild-typen: 4.77E-11
- Reference: 17644531
- Protein 1: HLA-A2 plus NY-ESO peptide
- Protein 2: 1G4 TCR
- Method: SPR
- Temperaute: 298(assumed) K
- Kon mutatant (M-1s-1): 1.78E+04
- Kon wild-type (M-1s-1): 5.7E+05
- Koff mutatant (M-1s-1): 1.45E-03
- Koff wild-type (M-1s-1): 2.72E-05
- ΔH mutant (kcal mol-1)): None
- ΔH wild-type (kcal mol-1)): None
- ΔS mutant (cal mol-1 K-1): None
- ΔS wild-type (cal mol-1 K-1): None