SKEMPI v2.0
Structural database of Kinetics and Energetics of Mutant Protein Interactions
1CZ8_HL_VW
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- Mutation(s) in PDB:
LL4M,
HH31N,
YH101H,
TH105S
- Mutation(s) cleaned: LL4M,HH31N,YH101H,TH105S
- Location: INT,COR,COR,RIM
- Hold out type: AB/AG
- Hold out protein(s): AB/AG
- Affinity mutant: 2E-09
- Affinity wild-typen: <1.4E-10
- Reference: 10543973
- Protein 1: Fab-12
- Protein 2: VEGF
- Method: SPR
- Temperaute: 298 K
- Kon mutatant (M-1s-1): 6.8E+04
- Kon wild-type (M-1s-1): 4.1E+04
- Koff mutatant (M-1s-1): 1.4E-04
- Koff wild-type (M-1s-1): 1.2E-04
- ΔH mutant (kcal mol-1)): None
- ΔH wild-type (kcal mol-1)): None
- ΔS mutant (cal mol-1 K-1): None
- ΔS wild-type (cal mol-1 K-1): None