SKEMPI v2.0
Structural database of Kinetics and Energetics of Mutant Protein Interactions
2DVW_A_B
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- Mutation(s) in PDB:
DA39A,
DA71A
- Mutation(s) cleaned: DA37A,DA69A
- Location: COR,RIM
- Hold out type:
- Hold out protein(s): 2DVW_A_B,4HRN_A_D,3AAA_AB_C
- Affinity mutant: 9.3E-08
- Affinity wild-typen: 6.73E-08
- Reference: 25343477
- Protein 1: Gankyrin
- Protein 2: S6 ATPase
- Method: ITC
- Temperaute: 298 K
- Kon mutatant (M-1s-1): -
- Kon wild-type (M-1s-1): -
- Koff mutatant (M-1s-1): -
- Koff wild-type (M-1s-1): -
- ΔH mutant (kcal mol-1)): -25.0
- ΔH wild-type (kcal mol-1)): -28.7
- ΔS mutant (cal mol-1 K-1): -51.677852349
- ΔS wild-type (cal mol-1 K-1): -63.76