SKEMPI v2.0
Structural database of Kinetics and Energetics of Mutant Protein Interactions
2SIC_E_I
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- Mutation(s) in PDB:
MI73A
- Mutation(s) cleaned: MI67A
- Location: COR
- Hold out type: Pr/PI
- Hold out protein(s): Pr/PI
- Affinity mutant: 2.6E-11
- Affinity wild-typen: 1.8E-11
- Reference: 8276767
- Protein 1: Subtilisin BPN
- Protein 2: Streptomyces subtilisin inhibitor
- Method: IASP
- Temperaute: 298 K
- Kon mutatant (M-1s-1): 3.7E+06
- Kon wild-type (M-1s-1): 6.5E+06
- Koff mutatant (M-1s-1): 1.4E-04
- Koff wild-type (M-1s-1): 9E-05
- ΔH mutant (kcal mol-1)): None
- ΔH wild-type (kcal mol-1)): None
- ΔS mutant (cal mol-1 K-1): None
- ΔS wild-type (cal mol-1 K-1): None