SKEMPI v2.0
Structural database of Kinetics and Energetics of Mutant Protein Interactions
4RA0_A_C
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- Mutation(s) in PDB:
SC32G,
GC87D,
AC92V,
RC127G
- Mutation(s) cleaned: SC6G,GC61D,AC66V,RC101G
- Location: SUR,INT,SUP,SUR
- Hold out type:
- Hold out protein(s): 2C5D_A_C,4RA0_A_C,2C5D_AB_CD
- Affinity mutant: 3.3E-11
- Affinity wild-typen: 2.7E-12
- Reference: 25242553
- Protein 1: GAS6
- Protein 2: Axl
- Method: KinExA
- Temperaute: 298(assumed) K
- Kon mutatant (M-1s-1): 2.1E+07
- Kon wild-type (M-1s-1): 1.6E+07
- Koff mutatant (M-1s-1): 7E-04
- Koff wild-type (M-1s-1): 4E-05
- ΔH mutant (kcal mol-1)): None
- ΔH wild-type (kcal mol-1)): None
- ΔS mutant (cal mol-1 K-1): None
- ΔS wild-type (cal mol-1 K-1): None