SKEMPI v2.0
Structural database of Kinetics and Energetics of Mutant Protein Interactions
4G0N_A_B
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- Mutation(s) in PDB:
VB88A
- Mutation(s) cleaned: VB35A
- Location: COR
- Hold out type:
- Hold out protein(s): 4G0N_A_B,3KUD_A_B,1LFD_A_B,1GUA_A_B,1C1Y_A_B,1K8R_A_B,1HE8_A_B,1E96_A_B
- Affinity mutant: 9.45E-08
- Affinity wild-typen: 8.02E-08
- Reference: 15236966
- Protein 1: H-Ras1
- Protein 2: Raf-RBD
- Method: ITC
- Temperaute: 308 K
- Kon mutatant (M-1s-1): -
- Kon wild-type (M-1s-1): -
- Koff mutatant (M-1s-1): -
- Koff wild-type (M-1s-1): -
- ΔH mutant (kcal mol-1)): -8.0
- ΔH wild-type (kcal mol-1)): -8.6
- ΔS mutant (cal mol-1 K-1): 6.1688311688
- ΔS wild-type (cal mol-1 K-1): 4.55