SKEMPI v2.0
Structural database of Kinetics and Energetics of Mutant Protein Interactions
1GUA_A_B
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- Mutation(s) in PDB:
EA37A
- Mutation(s) cleaned: EA37A
- Location: COR
- Hold out type:
- Hold out protein(s): 1GUA_A_B,1C1Y_A_B,4G0N_A_B,3KUD_A_B,1LFD_A_B,1K8R_A_B,1HE8_A_B
- Affinity mutant: 4.43E-06
- Affinity wild-typen: 4.93E-07
- Reference: 15236966
- Protein 1: Rap1a
- Protein 2: Raf-RBD
- Method: ITC
- Temperaute: 298 K
- Kon mutatant (M-1s-1): -
- Kon wild-type (M-1s-1): -
- Koff mutatant (M-1s-1): -
- Koff wild-type (M-1s-1): -
- ΔH mutant (kcal mol-1)): -2.7
- ΔH wild-type (kcal mol-1)): -5.6
- ΔS mutant (cal mol-1 K-1): 15.4362416107
- ΔS wild-type (cal mol-1 K-1): 10.067114094