SKEMPI v2.0
Structural database of Kinetics and Energetics of Mutant Protein Interactions
3EG5_A_B
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- Mutation(s) in PDB:
TB164N,
SB165N,
HB166N
- Mutation(s) cleaned: TB73N,SB74N,HB75N
- Location: COR,COR,SUP
- Hold out type:
- Hold out protein(s): 3EG5_A_B,1GRN_A_B,2REX_A_B,3Q3J_A_B
- Affinity mutant: 7.4E-06
- Affinity wild-typen: 1.25E-06
- Reference: 18829452
- Protein 1: M. musculus Cdc42
- Protein 2: MdiaN-TSH
- Method: ITC
- Temperaute: 293 K
- Kon mutatant (M-1s-1): -
- Kon wild-type (M-1s-1): -
- Koff mutatant (M-1s-1): -
- Koff wild-type (M-1s-1): -
- ΔH mutant (kcal mol-1)): 2.2
- ΔH wild-type (kcal mol-1)): 3.28
- ΔS mutant (cal mol-1 K-1): 31.023890785
- ΔS wild-type (cal mol-1 K-1): 38.2252559727