SKEMPI v2.0
Structural database of Kinetics and Energetics of Mutant Protein Interactions
1REW_AB_C
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- Mutation(s) in PDB:
KC88R,
SC90T,
KC92I,
AC93P,
QC94H,
LC95Q,
TC98D,
AC74T,
MC78L,
KC79G,
YC80L,
GC42H,
DC46E,
AC61T,
IC62M
- Mutation(s) cleaned: KC57R,SC59T,KC61I,AC62P,QC63H,LC64Q,TC67D,AC43T,MC47L,KC48G,YC49L,GC11H,DC15E,AC30T,IC31M
- Location: RIM,COR,RIM,COR,RIM,RIM,INT,INT,SUP,COR,RIM,RIM,RIM,INT,SUP
- Hold out type:
- Hold out protein(s): 1REW_AB_C,2QJ9_AB_C,2QJA_AB_C,2QJB_AB_C,1KTZ_A_B
- Affinity mutant: 4.9E-09
- Affinity wild-typen: 7E-10
- Reference: 18160401
- Protein 1: Bone morphogenetic protein-2
- Protein 2: BMPR-IA receptor
- Method: SPR
- Temperaute: 298(assumed) K
- Kon mutatant (M-1s-1): 2.8E+05
- Kon wild-type (M-1s-1): 3.4E+05
- Koff mutatant (M-1s-1): 1.11E-03
- Koff wild-type (M-1s-1): 2.4E-04
- ΔH mutant (kcal mol-1)): None
- ΔH wild-type (kcal mol-1)): None
- ΔS mutant (cal mol-1 K-1): None
- ΔS wild-type (cal mol-1 K-1): None